PEN-FAST

PEN-FAST reports a penicillin allergy. You learn he had a non-itching rash in his early 20s but no difficulty breathing or need for treatment. Is it appropriate to challenge his penicillin allergy with oral amoxicillin? How did others respond? Reveal the answer Best Answer: Yes challenge 💊 Explanation: This patient is at very low risk …

Antibiotics in Pancreatitis

Antibiotics in Pancreatitis presents to the with severe abdominal pain & WBCs. A CT scan shows acute pancreatitis without gas, abscess, or necrosis. Do they need antibiotics? How did others respond? Reveal the answer Best Answer No 🚫 Explanation: Antibiotics are NOT typically indicated in acute pancreatitis. Most cases are due to common noninfectious causes …

Altered Mental Status and Bacteriuria

Altered Mental Status and Bacteriuria presents with confusion . A urinalysis finds bacteria . Does she need antibiotics? Yes No Need more information How did others respond? Reveal the answer Best Answer Need more information Explanation: 2019 IDSA guidelines on asymptomatic bacteriuria (ASB) recommend to OBSERVE elderly patients OFF antibiotics if they do not have …

Duration of Therapy in Necrotizing Fasciitis

Duration of Therapy in Necrotizing Fasciitis presented with necrotizing fasciitis from Streptococcus pyogenes. After 3 debridements, no further surgery is planned. He is afebrile x 48 hours after his last surgery and improving He is on penicillin + clindamycin. What is the BEST antibiotic plan? A. No changeB. Stop clindamycin C. Stop penicillin D. Stop …

Group A Strep Necrotizing Fasciitis

Group A Strep Necrotizing Fasciitis presents with necrotizing fasciitis. cultures grow Streptococcus pyogenes (Group A Streptococcus). The team orders penicillin + clindamycin. Your student asks why clindamycin is added since penicillin covers GAS. You tell them… Anti-toxin effect C. difficile risk Penicillin resistance No reason How did others respond? Reveal the answer Best Answer Anti-toxin …

Azole Spectrum of Activity

Azole Spectrum of Activity is diagnosed with pulmonary aspergillosis Which azole antifungal would be the BEST to use for treatment? How did others respond? Reveal the answer Best Answer Voriconazole Explanation: Per IDSA guidelines, voriconazole is the drug of choice for Aspergillus spp. ✅ Fluconazole DOES NOT have activity against Aspergillus spp. & SHOULD NOT …

De-escalation

De-Escalation develops hospital-acquired pneumonia & started on empiric vancomycin + cefepime. Sputum cultures grow E. coli with the following susceptibilities: Ceftriaxone = S Cefepime = S Piperacillin/tazobactam = S How did others respond? Reveal the answer Best Answer: Ceftriaxone Explanation: Ceftriaxone will cover the E. coli 🦠 but does not unnecessarily cover Pseudomonas aeruginosa 🚫 …

S. pneumoniae Urinary Antigen

S. pneumoniae Urinary Antigen A presents complaining of a productive cough , shortness of breath & fever. He has a positive S. pneumoniae urine antigen. What is the MOST LIKELY scenario? A. S. pneumoniae UTIB. S. pneumoniae CAPC. S. pneumoniae immunity How did others respond? Reveal the answer Best Answer S. pneumoniae community-acquired pneumonia (CAP) 🫁 Explanation: The patient …

Streptococcus anginosus Group

Streptococcus anginosus Group A patient with Streptococcus anginosus bacteremia is discovered to have an abscess. Which of the following is the best empiric treatment option? A. Ampicillin/sulbactamB. CeftriaxoneC. Levofloxacin + flagyl How did others respond? Reveal the answer Best Answer 💉Ampicillin/sulbactam Streptococcus anginosus group (SAG) organisms are highly susceptible to penicillins, and the ➕ of …