Clostridioides difficile Prophylaxis A 70 year old with leukemia is admitted to the for febrile neutropenia. She was treated for C. difficile colitis last month. She is started on cefepime. She is not currently having diarrhea. Which is the BEST option? A. Test for C. difficileB. Start fidaxomicinC. Start oral vancomycin prophylaxis How did others respond? …
Coagulase-Negative Staphylococcus Bacteremia 3 patients are admitted to the hospital with coagulase-negative Staphylococcus spp. growing from blood cultures Patient 1 – 1 of 2 sets growing S. epidermidis with erythema at the catheter insertion site Patient 2 – 1 of 2 sets growing S. lugdunensis with NO symptoms Patient 3 – 1 of 2 sets …
Empiric Pip-Tazo in Intra-Abdominal Infections 2 patients are admitted & started on empiric piperacillin/tazobactam. Patient 1: with community-onset appendicitis Patient 2: with pancreatic cancer s/p recent Whipple with anastomotic leak & peritonitis In which patient is it REASONABLE to narrow antibiotics? How did others respond? Reveal the answer Best Answer: Patient 1 
Explanation: 2017 …
The Clinically Non-Responding Patient has a history of heart failure and is admitted for respiratory distress. He is diagnosed with pneumonia After 2 days, his oxygen requirements are but he is afebrile. Which is the MOST APPROPRIATE next action? How did others respond? Reveal the answer Best Answer: Evaluate fluid status Explanation: 
has a …
MRSA Nasal Screening After Vancomycin has pneumonia and is on day 5 of vancomycin. He has a history of MRSA No respiratory cultures have been collected. Should a MRSA swab be collected now? How did others respond? Reveal the answer Best Answer: No Explanation: The utility of MRSA 
swabs after anti-MRSA therapy is questionable …
Carbapenem-Resistant Acinetobacter baumannii is in the for pneumonia from carbapenem-resistant Acinetobacter baumannii (CRAB). She is started on minocycline. The team wants to use combination therapy Which is NOT an appropriate second agent? How did others respond? Reveal the answer Best Answer: Tigecycline Explanation: Sulbactam-containing antibiotics are the cornerstone of treating CRAB infections & should …
MRSA Nasal Screening in Diabetic Foot Infection is started on empiric vancomycin for a diabetic foot infection (DFI). His MRSA nasal screening is & he has NO history of MRSA Can vancomycin be STOPPED? How did others respond? Reveal the answer Best Answer: Yes, stop 
Explanation: A small study in patients with DFIs and …
MRSA Nasal Screen in Pneumonia 2 patients are admitted to the for pneumonia and started on empiric antibiotics including vancomycin. A MRSA screen is collected for both patients. Patient 1: CAP with septic shock and MRSA screen Patient 2: non-severe CAP and MRSA screen Which patient is the WORSE candidate for de-escalation off vancomycin? …
Fluoroquinolone Discordance is having a mild AECOPD and her sputum culture grows Pseudomonas aeruginosa Susceptibility is below: Levofloxacin = R Ciprofloxacin = S Cefepime = S Can ciprofloxacin be used for treatment? How did others respond? Reveal the answer Best Answer: Maybe 
Explanation: Ciprofloxacin appears to have better intrinsic activity against P. aeruginosa than …
Actinomyces has a relapsing skin abscess that has been present > 1 month. A culture eventually grows Actinomyces spp. Which drug is first line for treatment of Actinomycosis? How did others respond? Reveal the answer Best Answer: Penicillin Explanation: Penicillin is considered the drug of choice to treat Actinomycosis 
Alternative agents which may be …