Anaerobes in Diabetic Foot Infectionsby Matthew Songin Patient Caseson Posted on has a diabetic foot infection and is started on empiric ceftriaxone and vancomycin. The wound is without necrosis or gas formation and there are no concerns with limb ischemia. Should metronidazole be added? How did others respond? Reveal the answer Best Answer No Explanation: Anaerobic bacteria presence in DFI is often under-identified by conventional culture. Broad anaerobic coverage in DFIs is generally indicated only in the presence of necrosis, ischemia, or gas formation. Limited available data suggests that routine anaerobic coverage does not significantly impact outcomes, Click here for details/references