Quinolone Cross-Reactivity

by Matthew Songin Patient Caseson Posted on

A 44-year-old female is on day 3 pip-tazo for a complicated UTI. Her urine culture grows P. aeruginosa and she is ready to go home. She has a history of rash to ciprofloxacin. Can she be discharged on levofloxacin?

How did others respond?

Reveal the answer

Best Answer

Yes

Explanation: Patients with an allergy to one fluroquinolone are often able to tolerate a different fluroquinolone. Fluroquinolone immediate hypersensitivity cross-reactivity rates have been reported to low among ciprofloxacin (2.5%), levofloxacin (2.0%), and moxifloxacin (5.3%). When including delayed reactions as well, class cross-reactivity rates increase remain low 5.6% and follow a similar trend with moxifloxacin (9.5%) followed by ciprofloxacin (6.3%) and levofloxacin (2.2%).

Click here for details/references