Beta-Lactam Selection in CAP

Beta-Lactam Selection in Community-Acquired Pneumonia

A medical student is presenting on a patient with community-acquired pneumonia.

The team agrees they want to treat with a beta-lactam + macrolide. Which beta-lactam recommended per the 2019 ATS/IDSA guidelines is LOWEST risk for Clostridioides difficile?

A. Ampicillin/sulbactam
B. Cefotaxime
C. Ceftriaxone
D. Ceftaroline

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Best Answer:

Ampicillin/sulbactam

Though all these antibiotics can treat CAP, ampicillin/sulbactam has the lowest risk of Clostridioides difficile colitis. It also has limited activity against E. coli, which helps prevent future resistance 👍

Beta-Lactam Selection in Community-Acquired Pneumonia

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