Anaerobe Awareness in Intra-Abdominal Infections

is admitted to the with perforated diverticulitis & a blood culture growing PAN-SUSCEPTIBLE E. coli

What is the MOST appropriate antibiotic regimen?

A. Ampicillin
B. Ampicillin/sulbactam
C. Ceftriaxone

How did others respond?

Reveal the answer

Best Answer

Ampicillin/sulbactam

Explanation: Surgical Infection Society guidelines recommend anti-anaerobic activity in intra-abdominal infections, even when de-escalating. These organisms are difficult to grow in cultures and may still play a role in the infection 🦠

Some animal data 🐀🐇 and small cohort studies suggest that stopping broad-spectrum anaerobic activity may ⬆️ risk of abscess formation or septic complications.

Be anaerobe aware in intra-abdominal infections!