De-escalation

De-Escalation develops hospital-acquired pneumonia & started on empiric vancomycin + cefepime. Sputum cultures grow E. coli with the following susceptibilities: Ceftriaxone = S Cefepime = S Piperacillin/tazobactam = S How did others respond? Reveal the answer Best Answer: Ceftriaxone Explanation: Ceftriaxone will cover the E. coli 🦠 but does not unnecessarily cover Pseudomonas aeruginosa 🚫 …

S. pneumoniae Urinary Antigen

S. pneumoniae Urinary Antigen A presents complaining of a productive cough , shortness of breath & fever. He has a positive S. pneumoniae urine antigen. What is the MOST LIKELY scenario? A. S. pneumoniae UTIB. S. pneumoniae CAPC. S. pneumoniae immunity How did others respond? Reveal the answer Best Answer S. pneumoniae community-acquired pneumonia (CAP) 🫁 Explanation: The patient …

Streptococcus anginosus Group

Streptococcus anginosus Group A patient with Streptococcus anginosus bacteremia is discovered to have an abscess. Which of the following is the best empiric treatment option? A. Ampicillin/sulbactamB. CeftriaxoneC. Levofloxacin + flagyl How did others respond? Reveal the answer Best Answer 💉Ampicillin/sulbactam Streptococcus anginosus group (SAG) organisms are highly susceptible to penicillins, and the ➕ of …

Anti-pseudomonals

Anti-pseudomonals A patient with osteomyelitis due to P. aeruginosa is going home with antibiotic therapy. Which antibiotic is NOT an option? Ertapenem Cefepime Ciprofloxacin How did others respond? Reveal the answer Best Answer Ertapenem Explanation: Ertapenem is not active 🛑 against Pseudomonas aeruginosa. Cefepime and ciprofloxacin are both options but remember quinolones are the ONLY …

Procalcitonin in AECOPD

Procalcitonin in AECOPD A patient presents to the hospital in an AECOPD. They have severe dyspnea, increased sputum volume, and purulence. Their procalcitonin is 0.06 ng/mL. Should this patient be started on antibiotics ? How did others respond? Reveal the answer Best Answer ✅ Yes Explanation: The GOLD guidelines recommend patients with the cardinal symptoms …

Linezolid or Vancomycin for MRSA Pneumonia

Linezolid or Vancomycin for MRSA Pneumonia A was recently in the for influenza.   He is readmitted 2 weeks later with pneumonia. Which EMPIRIC anti-MRSA agent is the best choice?1. Vancomycin2. Linezolid How did others respond? Reveal the answer Best Answer Vancomycin Explanation: Using empiric vancomycin can help preserve linezolid activity against vancomycin-resistant Enterococcus. Positioning …

Procalcitonin in Pneumonia

Procalcitonin in Pneumonia 3 patients with pneumonia on day 5 of antibiotics have a procalcitonin level drawn. PCT = 0.6 mcg/mL PCT = 0.1 mcg/mL PCT = 3.6 mcg/mL (was initially 7.2 mcg/mL) Who can most likely STOP antibiotics based on procalcitonin? How did others respond? Reveal the answer Best Answer Patient 2 👩🏻‍🦰 Explanation: …

Cefazolin vs Antistaphylococcal Penicillins

Cefazolin vs Antistaphylococcal Penicillins In which of the following patients would cefazolin be ADVANTAGEOUS over nafcillin for treatment of a MSSA infection? Patient 1 with CNS infection & recent C. difficile Patient 2 with osteomyelitis & hyperkalemia & LFTs How did others respond? Reveal the answer Best Answer Patient 2 🧔🏼 Explanation: Cefazolin is favorable …