TMP/SMX for Cellulitis

undergoes I&D in the emergency room and is sent home with TMP/SMX

Wound culture grows MRSA & Streptococcus pyogenes

Do antibiotics need to be changed?

How did others respond?

Reveal the answer

Best Answer:

Explanation: TMP/SMX is active against MRSA and beta-hemolytic Streptococcus spp. Historically, it was thought TMP/SMX was INACTIVE against Streptococcus, but this was due to use of older microbiological testing techniques 🔬

2 randomized controlled trials compared TMP/SMX to alternatives like beta-lactams or clindamycin and found NO DIFFERENCE in clinical cure, including in non-purulent infections likely caused by Streptococcus 🎉