Clostridioides difficile Prophylaxis
A 70 year old 
with leukemia is admitted to the 
for febrile neutropenia. She was treated for C. difficile colitis last month.
She is started on cefepime. She is not currently having diarrhea. Which is the BEST option?
A. Test for C. difficile
B. Start fidaxomicin
C. Start oral vancomycin prophylaxis
How did others respond?
Reveal the answer
Best Answer:
Start oral vancomycin prophylaxis
Explanation: The 2021 American College of Gastroenterology guidelines suggest consideration of oral vancomycin prophylaxis in patients at HIGH RISK of recurrence when treating with systemic antibiotics 💊
👵🏻 is high risk due to her age and immunocompromised status. She is not symptomatic so no testing is indicated currently.