Daptomycin and Myopathy A is getting daptomycin outpatient for MRSA endocarditis. After 2 weeks, he has muscle pain and CK= 500. Daptomycin is stopped. What home medication could have increased his risk of myopathy and rhabdomyolysis? A) AmlodipineB) ApixabanC) AtorvastatinD) All of the above How did others respond? Reveal the answer Best Answer Atorvastatin Explanation: …
Linezolid Drug Interaction A 60 year old with a vancomycin-resistant Enterococcus infection is being discharged to finish a treatment course with linezolid Which of his home medications COULD interact with linezolid? A) Amlodipine B) Citalopram C) Dabigatran D) Rosuvastatin How did others respond? Reveal the answer Best Answer Citalopram Explanation: Linezolid has weak monoamine-oxidase inhibitor …
Aztreonam Spectrum of Activity A 45 year old is admitted to the with cough and a new infiltrate on chest X-ray She has a cephalosporin allergy and aztreonam is ordered Which possible pathogen does aztreonam NOT cover? Answer: A) H. influenzae B) M. catarrhalis C) S. pneumoniae D) P. aeruginosa How did others respond? Reveal the answer Best Answer S. pneumoniae Explanation: Aztreonam …
Antibiotic-Induced Confusion 82 year old with CKD is admitted to the 2/2 STEMI. She is intubated in the ICU and days later has a new fever Antibiotics are started to cover MRSA + Pseudomonas spp. 4 days later, she has new confusion. Which antibiotic is most likely causing ? A. Linezolid B. Vancomycin C. Cefepime …
Uncomplicated Abscess A 78 year old presents to a ED in the with LLE pain/redness + fever not improving on 2 days of cephalexin. Exam reveals a 2 cm abscess. I&D is done & the patient is stable. What is the best antibiotic plan? A. ClindamycinB. DoxycyclineC. CephalexinD. Hold Antibiotics How did others respond? Reveal …
Ceftazidime Spectrum of Activity A 55-year oldis admitted to the with a productive cough and fever and started on empiric ceftazidime. Ceftazidime provides reliable coverage against ALL of the following bacteria EXCEPT…? A. MSSAB. Klebsiella sppC. Pseudomonas aeruginosaD. E. coli How did others respond? Reveal the answer Best Answer MSSA Explanation: Ceftazidime has NO activity …
VRE Cystitis A 40 year old presents with persistent dysuria despite taking cephalexin as prescribed Her previous urine culture grew Enterococcus faecium with the following susceptibility. Ampicillin RVancomycin RDaptomycin SDD What is the best therapy? A. AmoxicillinB. ClindamycinC. TMP-SMXD. Daptomycin How did others respond? Reveal the answer Best Answer Amoxicillin Explanation: Ampicillin is a surrogate …
Acute Bacterial Meningitis A 30 year old with no significant PMH presents with fever + neck stiffness + severe headache. What is the best empiric therapy for bacterial meningitis? VAN = vancomycinCRO = ceftriaxoneAMP = ampicillinDEX = dexamethasone A. VAN + CROB. VAN + CRO + AMPC. VAN + CRO + DEX How did others …
Antibiotic Drug Interactions A with epilepsy managed with valproic acid is admitted to the with undifferentiated shock. He is started on empiric antibiotics. Three (3) days later he has a seizure. His valproic acid level is undetectable despite receiving inpatient doses What antibiotic was likely started? A. Ciprofloxacin B. TMP/SMX C. Meropenem D. Vancomycin How …
Penicillin Allergy Management A 26 year old pregnant femalewith known Group B Streptococcus colonization is admitted for delivery. She has a history of a penicillin allergy. Her parent told her she had a rash as a child but she has no further details . What GBS prophylaxis should be used? A) ClindamycinB) CefazolinC) Vancomycin How did others …