Beat the Bug: Lactobacillus spp
Beat the Bug: Lactobacillus spp A patient started on empiric ceftriaxone and metronidazole is found to have Lactobacillus rhamnosus bacteremia. Should the antibiotics be changed? How did others respond? Reveal the answer Best Answer Yes Explanation: Lactobacillus spp. can cause clinically significant infections, and usual treatment includes penicillin or broader spectrum options, if needed. Penicillin, …
Linezolid for Line Infections
Know Your Antibiotic: Nitrofurantoin
Know Your Antibiotic: Nitrofurantoin A patient is prescribed nitrofurantoin for an uncomplicated UTI in the ED and sent home. Two days later, the urine culture results with P. mirabilis. Should the antibiotic be changed? How did others respond? Reveal the answer Best Answer Yes Explanation: Nitrofurantoin is a preferred option for the management of UTIs …
What To Do When the Vanc MIC is 2?
β-lactam/β-lactamase Inhibitors for MSSA
β-lactam/β-lactamase Inhibitors for MSSA A patient is on empiric piperacillin-tazobactam and found to have MSSA bacteremia. Is de-escalating piperacillin-tazobactam to cefazolin urgent ? How did others respond? Reveal the answer Best Answer Yes Explanation: Beta-lactam/beta-lactamase inhibitors (BLBLIs) such as piperacillin-tazobactam are active against MSSA, but microbiological and observational clinical data suggest worse outcomes compared to …
Amoxicillin-Clavulanate for ESBL UTIs
Amoxicillin-Clavulanate for ESBL UTIs A patient is prescribed cephalexin for a UTI by her primary care doctor. Two days later an ESBL P. mirabilis grows in culture. The only susceptible oral antibiotic is amoxicillin-clavulanate. Should she be admitted for IV antibiotics? How did others respond? Reveal the answer Best Answer Maybe Explanation: The IDSA suggests …
Know Your Antibiotic: Nitrofurantoin
Hemodialysis-only Antibiotic Dosing
Hemodialysis-only Antibiotic Dosing A patient with a history of chronic HD has been receiving treatment for complicated MSSA bacteremia and is clinically stable for discharge. Ok to complete treatment with thrice weekly cefazolin at the outpatient HD center? How did others respond? Reveal the answer Best Answer Yes Explanation: Cefazolin is primarily renally cleared, therefore …