Linezolid For Line Infections

A patient presents with pain and erythema around a PICC line. The line was removed, blood cultures grew CoNS, and the patient is ready to go home. Is PO linezolid an option?

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Yes

Explanation: Linezolid is a recommended option as definitive therapy in CRBSIs due to a gram-positive pathogen. In one RCT, empiric treatment that included linezolid resulted in increased mortality in patients with catheter-related infections with gram-negative bacteremia or negative cultures. It is unclear if linezolid was the cause of this, but due to the availability of alternatives, it is recommended to avoid linezolid as empiric therapy for CRBSI.

Linezolid For Line Infections

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