Explanation: Per IDSA guidelines, voriconazole is the drug of choice for Aspergillus spp. ✅

Fluconazole DOES NOT have activity against Aspergillus spp. & SHOULD NOT be used for treatment of this kind of infection🚫

Azole antifungals differ in their spectrum of activity and cannot be used interchangeably. As voriconazole is the drug of choice for Aspergillus 🍄 infection, it should be used FIRST LINE if there are no contraindications