β-lactam/β-lactamase Inhibitors for MSSA - KASIC

β-lactam/β-lactamase Inhibitors for MSSA

A patient is on empiric piperacillin-tazobactam and found to have MSSA bacteremia. Is de-escalating piperacillin-tazobactam to cefazolin urgent ?

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Best Answer

Yes

Explanation: Beta-lactam/beta-lactamase inhibitors (BLBLIs) such as piperacillin-tazobactam are active against MSSA, but microbiological and observational clinical data suggest worse outcomes compared to anti-staphylococcal penicillins or cefazolin. Potentially improving efficacy is another reason to de-escalate from broader spectrum BLBLIs in serious MSSA infections.

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