Hemodialysis-only Antibiotic Dosing

A patient with a history of chronic HD has been receiving treatment for complicated MSSA bacteremia and is clinically stable for discharge. Ok to complete treatment with thrice weekly cefazolin at the outpatient HD center?

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Yes

Explanation: Cefazolin is primarily renally cleared, therefore high concentrations are achieved and sustained in between dialysis sessions for patients on chronic HD. Thrice weekly IV antibiotic dosing is available with select antibiotics in patients receiving chronic HD. Dosing through HD access may preserve vascular access and be logistically easier.

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