Cefdinir PO For Bacteremic UTI - KASIC

Cefdinir PO for Bacteremic UTI

A patient is being discharged on cefdinir 300 mg PO BID for E. coli bacteremia secondary to a cUTI. Is this an appropriate discharge plan?

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Best Answer

No

Explanation: Cefdinir is unable to reach appropriate serum target attainment for typical MICs of Enterobacterales. Clinical outcomes data also suggest that use of cefdinir as PO stepdown therapy is associated with bacteremia/UTI recurrence and rehospitalization compared with quinolones and TMP-SMX. Cefdinir may also be inferior to other beta-lactams.

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