De-escalation is For Everyone

An ICU patient is on day 3 of empiric antibiotics for pneumonia. The patient is improving and cultures are negative. Which of the following is a benefit from antimicrobial de-escalation?

A. Lower AKI risk
B. Higher mortality
C. Cost increases

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Best Answer

Lower AKI risk
Antimicrobial de-escalation has been shown to decrease risk for acute kidney injury, ICU admission, in-hospital mortality, and can also be a cost-saving opportunity. Antimicrobial de-escalation is appropriate in any clinically improving patient, including ICU patients, and those with negative cultures.

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