Penicillin Allergy History

Two patients are admitted with neurosyphilis and penicillin allergies.

1: father was penicillin allergic, has not taken
2: difficulty breathing after 1st dose of amoxicillin

Which patient(s) likely require DESENSITIZATION to penicillin?

How did others respond?

Reveal the answer

Best Answer:

Patient 2 👱🏼‍♀️

Explanation: Patient 2 👱🏼‍♀️ has a previous SEVERE hypersensitivity reaction. She should undergo a desensitization then complete her penicillin therapy.

Patient 1 🧑🏻 is unlikely to have a severe IgE-mediated reaction to penicillin based on their history and proceeding with penicillin as normal is likely appropriate. If they tolerate penicillin without issue, they should be de-labeled!