Fluoroquinolone Discordance

is having a mild AECOPD and her sputum culture grows Pseudomonas aeruginosa

Susceptibility is below:
Levofloxacin = R
Ciprofloxacin = S
Cefepime = S

Can ciprofloxacin be used for treatment?

How did others respond?

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Best Answer:

Maybe

Explanation: Ciprofloxacin appears to have better intrinsic activity against P. aeruginosa than levofloxacin. However there is NO PUBLISHED DATA on clinical outcomes in quinolone discordant isolates. Clinicians should use their best judgement!

For example, in our patient with a mild infection oral ciprofloxacin is likely a reasonable choice to avoid IV therapy. Risk vs benefit should be weighed