Explanation: Ceftriaxone will cover the E. coli 🦠 but does not unnecessarily cover Pseudomonas aeruginosa 🚫

Cefepime and piperacillin/tazobactam are antipseudomonal agents and are NOT the most appropriate choice when a narrower spectrum agent can be used.

Reserving antipseudomonal agents when possible is an important antimicrobial stewardship strategy to preserve their utility ✅