Streptococcus anginosus group (SAG) organisms are highly susceptible to penicillins, and the ➕ of anaerobic coverage is recommended for SAG abscesses.

While ceftriaxone covers SAG, it does not ❌ provide anaerobic coverage. Levofloxacin is not first line due to unnecessary anti-pseudomonal activity and the possibility of SAG developing resistance while on therapy.

SAG has a high association with abscesses, and patients should be evaluated for an abscess in SAG bacteremia. Antibiotic treatment should be in conjunction with source control 🔪