Risk of C. difficile

3 patients are being discharged

amoxicillin x 5 days

cefdinir x 3 days

levofloxacin x 10 days

Whose antibiotic regimen is HIGHEST risk for C. difficile?

How did others respond?

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Best Answer

levofloxacin x 10 days

Explanation: ALL antibiotics risk of C. difficile infection but risk varies across classes. Fluoroquinolones & 3rd generation cephalosporins pose a HIGHER risk compared to penicillins.

C. difficile risk increases with longer length of therapy

C. difficile risk is TIMES HIGHER in patients who receive 8-18 days vs <4 days of antibiotics

When multiple antibiotic options are available, C. difficile risk by selecting lower risk or narrow spectrum agents and using the shortest effective duration!