Treatment of CRE

A is seen in clinic with recurrent pyelonephritis. Her urine culture grows K. pneumoniae with this susceptibility:

Meropenem = R
TMP/SMX = S
PIP/TAZ = I

What is the BEST antibiotic choice based on available data?

A. TMP/SMX
B. Ciprofloxacin
C. Ceftazidime/Avibactam
D. Cefiderocol

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TMP/SMX

Explanation: Based on meropenem resistance this isolate is a carbapenem-resistant Enterobacterales (CRE). 2023 IDSA Guidance recommends using TMP/SMX in CRE urinary tract infections if the bacteria is susceptible 🦠

Treating CREs can be challenging! To pick the best therapy, think about:

-site of infection 🫀🫁🧠🫘
-susceptibilities 🧫
-genetic data (if available) 🧬

Keep your cool when treating CRE!

Treatment of CRE

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