Antibiotic Drug Interactions

with epilepsy managed with valproic acid is admitted to the

with undifferentiated shock. He is started on empiric antibiotics. Three (3) days later he has a seizure. His valproic acid level is undetectable despite receiving inpatient doses

What antibiotic was likely started?

A. Ciprofloxacin
B. TMP/SMX
C. Meropenem
D. Vancomycin

How did others respond?

Reveal the answer

Best Answer

Meropenem

Explanation: Carbapenems will lower valproic acid levels within 24 hours of starting combination therapy. This interaction CANNOT be overcome by increasing the valproic acid dose. Either an alternative anti-epileptic drug or alternative antibiotic should be utilized.